Have you played through your Cards Against Humanity sets one too many times? Can your friends just say "Auschwitz" or "Bigger, Blacker Dick" and trump the cards on the table?
Checkout F**ktionary, a mashup of Balderdash and Urban Dictionary.
In turn, a term from a card is read alound and the rest of the players have to come up with a definition for it. The submitted answers, and the real one provided on the card, are then read aloud, and players vote for the one they think is correct. The winning answers gives a point to the player who wrote it.
Sounds like a good time, but our friends might be a little too hammered to write legible descriptions. We'll have to see.